Eversole L R, Fleischmann J, Baldwin G C, Sapp J P
Section of Diagnostic Sciences, University of California at Los Angeles, School of Dentistry 90024, United States.
Oral Microbiol Immunol. 1994 Feb;9(1):55-9. doi: 10.1111/j.1399-302x.1994.tb00215.x.
The effects of infection by human immunodeficiency virus (HIV) on phagocytic function towards Candida pseudotropicalis were tested using monocytotropic and nonmonocytotropic HIV strains on peripheral blood monocytes. There were no differences in either quantitative phagocytic activity or efficacy between the two infected and control mock-infected monocytes. Immunofluorescence for cytoplasmic p24 antigen and in situ hybridization for detection of HIV-specific RNA sequences revealed that very few cells (10(-4)) exhibit productive infection. Occasional cells with active infection as defined by microscopically detectable fluorescence labelling contained phagocytized yeasts.
使用嗜单核细胞和非嗜单核细胞HIV毒株对外周血单核细胞进行检测，以研究人类免疫缺陷病毒（HIV）感染对其吞噬假热带念珠菌功能的影响。在两种感染的单核细胞与对照模拟感染的单核细胞之间，定量吞噬活性或功效均无差异。细胞质p24抗原的免疫荧光和用于检测HIV特异性RNA序列的原位杂交显示，极少细胞（10⁻⁴）呈现出有效感染。显微镜下可检测到的荧光标记所定义的偶尔有活跃感染的细胞含有吞噬的酵母。
