Gay G R, Kirkman J H, Alexander G A, Rappolt R T
Clin Toxicol. 1978;13(4):487-504. doi: 10.3109/15563657808988254.
The respiratory stimulant doxapram hydrochloride has long been shunned in the United States because of a perpetuated fear of the alleged side effects of hypertension and tachycardia with attendant hypermetabolism and increased oxygen consumption. This study reports the results of the administration of doxapram alone, and of doxapram in conjunction with the beta-blocker propranolol on the blood pressure, heart rate, and respiratory rate of 12 healthy unanesthetized volunteer subjects. Results showed an augmentation in blood pressure (especially diastolic), a significant decrease in heart rate, and an unexpected actual increase in respiratory rate in the doxapram/propranolol group. Subtleties of sympathetic balance, as well as proposed future studies are discussed.
长期以来，呼吸兴奋剂盐酸多沙普仑在美国一直备受冷落，因为人们一直担心它会引发高血压、心动过速以及随之而来的代谢亢进和耗氧量增加等所谓的副作用。本研究报告了单独使用多沙普仑以及多沙普仑与β受体阻滞剂普萘洛尔联合使用对12名未麻醉的健康志愿者受试者的血压、心率和呼吸频率的影响结果。结果显示，多沙普仑/普萘洛尔组的血压升高（尤其是舒张压）、心率显著降低，且呼吸频率意外地实际增加。文中讨论了交感神经平衡的微妙之处以及未来拟开展的研究。
