Moczulski D, Grzeszczak W, Zukowska-Szczechowska E A, Pyzik K, Sawiniak M
Katedry i Kliniki Chorób Wewnetrznych i Zawodowych Slaskiej AM w Zabrzu.
Pol Arch Med Wewn. 1995 Jan;93(1):32-40.
Patients with chronic renal failure (CRF) have high serum prolactin level. In healthy subjects the circadian rhythm of prolactin secretion is well known. This study aimed to investigate, if the circadian rhythm of prolactin was maintained in patients with CRF treated with haemodialysis despite hyperprolactinaemia, and how the treatment with erythropoietin influenced the circadian rhythm of prolactin. Serum prolactin was determined four times a day at 6:00, 12:00, 18:00, 24:00 in 30 patients with CRF and in 15 healthy subjects. In the patients with CRF this investigation was both done on the day with haemodialysis and on the day without haemodialysis. The patients were divided into two groups: the first one included patients treated with erythropoietin and the second one included patients not treated with erythropoietin. The results of the investigation were analysed using the Cosinor test. Serum concentration of hormones was determined by LIA. It was shown that the circadian rhythm of prolactin was maintained in patients with CRF both on the day with and without haemodialysis. Both in patients with CRF and in healthy subjects the circadian rhythm indicated the highest serum concentration of prolactin in the night hours i.e. 22:30-1:00. In patients treated with erythropoietin a significantly lower average day concentration of prolactin was observed in comparison with patients not treated with erythropoietin.
慢性肾衰竭（CRF）患者血清催乳素水平较高。在健康受试者中，催乳素分泌的昼夜节律是众所周知的。本研究旨在调查接受血液透析治疗的CRF患者尽管存在高催乳素血症，但催乳素的昼夜节律是否维持，以及促红细胞生成素治疗如何影响催乳素的昼夜节律。在30例CRF患者和15例健康受试者中，于每天6:00、12:00、18:00、24:00测定血清催乳素。对于CRF患者，在进行血液透析的当天和未进行血液透析的当天均进行此项研究。患者分为两组：第一组包括接受促红细胞生成素治疗的患者，第二组包括未接受促红细胞生成素治疗的患者。使用余弦分析检验对研究结果进行分析。通过免疫放射分析测定激素的血清浓度。结果显示，无论有无血液透析，CRF患者催乳素的昼夜节律均得以维持。在CRF患者和健康受试者中，昼夜节律均表明夜间即22:30 - 1:00时血清催乳素浓度最高。与未接受促红细胞生成素治疗的患者相比，接受促红细胞生成素治疗的患者观察到平均日间催乳素浓度显著降低。
