在雄性对照动物外周给药后，生长激素释放激素（GHRH）而非生长抑素（SRIF）诱发的听觉诱发电位晚期变化。

Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls.

作者信息

Hartmann A, Dietl T, Krumrey K, Vogl L, Dirlich G, Holsboer F, Heuser-Link M

机构信息

Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany.

出版信息

Peptides. 1995;16(4):657-63. doi: 10.1016/0196-9781(95)00024-e.

DOI:10.1016/0196-9781(95)00024-e

PMID:7479300

Abstract

To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and further analyzed by using the brain electric source analysis (BESA) method. Reduced late AEP latencies were observed following GHRH administration. In contrast, SRIF had no significant effects on the AEP. The changes in late auditory processing seen after administration of GHRH were most likely induced by a direct central nervous action.

摘要

为研究生长激素释放激素（GHRH）和生长抑素（SRIF）对听觉感知过程可能产生的影响，12名受试者在不同日期分别接受了安慰剂（0.9%氯化钠）、GHRH（50微克）或SRIF（100微克）。计算了晚期听觉诱发电位（AEP），并采用脑电源分析（BESA）方法进行进一步分析。给予GHRH后观察到晚期AEP潜伏期缩短。相比之下，SRIF对AEP没有显著影响。给予GHRH后晚期听觉处理的变化很可能是由直接的中枢神经作用引起的。