Kontinen V K, Kalso E A
Department of Anesthesia, University of Helsinki, Finland.
Peptides. 1995;16(5):973-7. doi: 10.1016/0196-9781(95)00068-u.
Neuropeptide FF (NPFF) has been found to act as an antiopioid peptide. However, IT NPFF has recently been shown to potentiate the antinociceptive effects of IT morphine and to produce antinociception on its own. The aim of this study was to find out whether pretreatment with NPFF causes a comparable potentiation of dexmedetomidine-induced antinociception. NPFF (0.05-10.0 nmol) produced no antinociceptive effects in the rat tail flick test. NPFF potentiated the antinociceptive effect of IT morphine (7.8 nmol). This potentiation was prevented by IT naltrindole (28 nmol), which did not attenuate the antinociceptive effect of morphine. Dexmedetomidine (1.6-6.4 nmol) produced a dose-dependent antinociceptive effect, which was not potentiated by NPFF. Activation of the endogenous delta-opioid system due to the antiopioid effect of IT NPFF is proposed as an explanation to the reported differential action of NPFF on the mu-opioid and the alpha 2-adrenergic systems.
神经肽FF（NPFF）已被发现可作为一种抗阿片肽。然而，最近研究表明，鞘内注射NPFF可增强鞘内注射吗啡的镇痛作用，且其自身也能产生镇痛效果。本研究的目的是探究NPFF预处理是否能增强右美托咪定诱导的镇痛作用。在大鼠甩尾试验中，NPFF（0.05 - 10.0纳摩尔）未产生镇痛效果。NPFF增强了鞘内注射吗啡（7.8纳摩尔）的镇痛作用。鞘内注射纳曲吲哚（28纳摩尔）可阻止这种增强作用，而纳曲吲哚并未减弱吗啡的镇痛作用。右美托咪定（1.6 - 6.4纳摩尔）产生剂量依赖性镇痛作用，且未被NPFF增强。由于鞘内注射NPFF的抗阿片作用导致内源性δ-阿片系统激活，这被认为是NPFF对μ-阿片系统和α2-肾上腺素能系统产生不同作用的原因。
