Soares P, Sobrinho-Simões M
Department of Pathology, Medical Faculty of Porto, Portugal.
Pathol Res Pract. 1995 May;191(4):304-17. doi: 10.1016/S0344-0338(11)80884-8.
In this review we summarize the most recent advances of flow and image cytometry, cytogenetics and molecular genetics of tumours and tumour-like lesions of the thyroid, especially focusing on the putative relationship between nodular goitres and adenomas, the differential diagnosis of benign and malignant neoplasms and the pathogenesis and prognosis of carcinomas. Data obtained by in situ hybridization and immunohistochemical detection of proliferative markers, metal binding proteins and oncogenes, anti-oncogenes, growth factors and growth factor receptors are also used whenever appropriate.
在本综述中，我们总结了甲状腺肿瘤及肿瘤样病变在流式细胞术、图像细胞术、细胞遗传学和分子遗传学方面的最新进展，尤其关注结节性甲状腺肿与腺瘤之间的假定关系、良恶性肿瘤的鉴别诊断以及癌的发病机制和预后。只要适用，还会使用通过原位杂交以及对增殖标志物、金属结合蛋白、癌基因、抗癌基因、生长因子和生长因子受体进行免疫组化检测所获得的数据。
