Hara H, Narakino H, Kiriyama S
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan.
Pancreas. 1995 Aug;11(2):173-8. doi: 10.1097/00006676-199508000-00010.
Diversion of bile-pancreatic juice (BPJ) causes exocrine pancreatic hypersecretion in a fasting state, and we demonstrated that a feeding of dietary protein stimulates further secretion of pancreatic enzymes in chronic BPJ-diverted rats. We determined that gastric acid secretion is associated with the stimulatory effect of dietary protein feeding on pancreatic secretion in the diverted rats. BPJ was diverted with a cannula of the common bile-pancreatic duct and returned to the upper ileum for 7 days. The BPJ-diverted rats were administered omeprazole (12 mg/kg body weight) orally and were fed a 25% casein, fat-free diet spontaneously under unrestrained conditions. The volume of BPJ was not changed after administration of omeprazole and feeding the diet. Total protein, amylase, and chymotrypsin secretions were not changed 1 h after omeprazole administration but increased gradually after feeding the diet. The secretion of these enzymes reached peak values 120-150 min after feeding, and these values were two- to threefold higher than those before feeding. We conclude that gastric acid secretion is not responsible for the stimulation of pancreatic secretion that occurs after feeding a dietary protein to chronic BPJ-diverted rats.
胆汁胰液（BPJ）改道会在禁食状态下导致胰腺外分泌亢进，并且我们证明，给慢性BPJ改道大鼠喂食膳食蛋白会刺激胰腺酶进一步分泌。我们确定胃酸分泌与给改道大鼠喂食膳食蛋白对胰腺分泌的刺激作用有关。用胆总管和胰管插管使BPJ改道，并使其回流至回肠上段7天。给BPJ改道大鼠口服奥美拉唑（12毫克/千克体重），并在无限制条件下让其自由采食25%酪蛋白无脂饮食。给予奥美拉唑并喂食该饮食后，BPJ的量未发生变化。奥美拉唑给药1小时后，总蛋白、淀粉酶和糜蛋白酶分泌未发生变化，但喂食饮食后逐渐增加。这些酶的分泌在喂食后120 - 150分钟达到峰值，这些值比喂食前高两到三倍。我们得出结论，胃酸分泌与给慢性BPJ改道大鼠喂食膳食蛋白后发生的胰腺分泌刺激无关。
