一种预测的蛋白激酶C2同源性（C2H）结构域的共有结构，突触结合蛋白的重复单元。

A predicted consensus structure for the protein kinase C2 homology (C2H) domain, the repeating unit of synaptotagmin.

作者信息

Gerloff D L, Chelvanayagam G, Benner S A

机构信息

Department of Chemistry, Swiss Federal Institute of Technology, Zurich, Switzerland.

出版信息

Proteins. 1995 Aug;22(4):299-310. doi: 10.1002/prot.340220402.

DOI:10.1002/prot.340220402

PMID:7479705

Abstract

A secondary structure has been predicted for the protein kinase C2 regulatory domain found in homologous form in synaptotagmin, some phospholipases, and some GTP activated proteins. The proposed structure is built from seven consecutive beta strands followed by a terminal alpha helix. Considerations of overall surface exposure of individual secondary structural elements suggest that these are packed into a 2-sheet beta sandwich structure, with one of only three of the many possible folds being preferred.

摘要

已预测出蛋白激酶C2调节结构域的二级结构，该结构域在突触结合蛋白、一些磷脂酶和一些GTP激活蛋白中以同源形式存在。所提出的结构由七条连续的β链组成，后面跟着一个末端α螺旋。对单个二级结构元件整体表面暴露情况的考虑表明，它们被包装成一个双β片层夹心结构，在众多可能的折叠形式中，只有三种折叠形式中的一种是首选的。