Pandey R K, Potter W R, Meunier I, Sumlin A B, Smith K M
Department of Radiation Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Photochem Photobiol. 1995 Oct;62(4):764-8. doi: 10.1111/j.1751-1097.1995.tb08727.x.
A first report on the biological evaluation of a series of isomerically pure benzoporphyrin derivatives (cis- and trans-isomers) as methyl esters is described. In preliminary in vivo studies, the n-hexyl ether analogues of both cis- and trans-isomers of benzoporphyrin derivatives were found to be more active than the industrially prepared benzoporphyrin derivative, a mixture of monocarboxylic acids (BPDMA, Quadralogic Technologies, Vancouver). Further studies with 4-de-vinyl-4- (1-hexyloxyethyl) benzoporphyrin derivative showed that, like BPDMA, it had reduced residual skin phototoxicity compared in mice with Photofrin. The uptake and clearance characteristics of BPDMA were also compared with the 4-(1-hexyloxyethyl)-derivative by in vivo reflection spectroscopy.
本文描述了一系列异构纯的苯并卟啉衍生物（顺式和反式异构体）甲酯的生物学评价的首次报告。在初步的体内研究中，发现苯并卟啉衍生物顺式和反式异构体的正己基醚类似物比工业制备的苯并卟啉衍生物（一元羧酸混合物，BPDMA，Quadralogic Technologies，温哥华）更具活性。对4-脱乙烯基-4-（1-己氧基乙基）苯并卟啉衍生物的进一步研究表明，与BPDMA一样，与Photofrin相比，它在小鼠体内的残余皮肤光毒性降低。还通过体内反射光谱法比较了BPDMA与4-（1-己氧基乙基）衍生物的摄取和清除特性。
