Keshavan M S, Pettegrew J W, Reynolds C F, Panchalingam K S, Montrose D, Miewald J, Kupfer D J
Department of Psychiatry, Western Psychiatric Institute, Pittsburgh, PA 15213-2593, USA.
Psychiatry Res. 1995 Jul 28;57(2):91-100. doi: 10.1016/0165-1781(95)02669-n.
Deficits in slow wave sleep (SWS) are consistently seen in schizophrenia and related psychotic disorders. However, the pathophysiological significance of this finding is uncertain. In 19 patients with psychotic illness, sleep and 31P-magnetic resonance spectroscopy (MRS) studies were carried out before the patients began medication treatment. Polysomnographic studies were carried out in 2-3 consecutive nights. MRS studies were performed with a surface coil and a depth-resolved pulse sequence focusing on the dorsal prefrontal cortex. Phosphomonoesters were correlated with visually scored delta and Stage 4 sleep, as well as with automated delta wave counts. An inverse relation was also seen between negative symptoms scores and SWS. The association between decreases brain anabolic processes (reflected by decreased PME) and decreased SWS may be related either to processes of accelerated aging or to developmentally mediated alterations in cortical synaptic pruning, postulated to underlie the pathophysiology of functional psychoses.
精神分裂症及相关精神障碍患者中经常出现慢波睡眠（SWS）不足。然而，这一发现的病理生理学意义尚不确定。对19例精神病患者在开始药物治疗前进行了睡眠和31P磁共振波谱（MRS）研究。连续2至3个晚上进行多导睡眠图研究。使用表面线圈和聚焦于背侧前额叶皮质的深度分辨脉冲序列进行MRS研究。磷酸单酯与视觉评分的δ波和4期睡眠以及自动δ波计数相关。阴性症状评分与SWS之间也存在负相关关系。大脑合成代谢过程减少（以PME降低为反映）与SWS减少之间的关联可能与加速衰老过程或皮质突触修剪中发育介导的改变有关，这些改变被认为是功能性精神病病理生理学的基础。
