Wollman S H, Herveg J P, Zeligs J D, Ericson L E
Endocrinology. 1978 Dec;103(6):2306-14. doi: 10.1210/endo-103-6-2306.
To study blood capillary growth in the hyperplastic thyroid gland, rats were fed 0.25% thiouracil in a low iodine diet for time intervals up to 100 days. Thyroids were fixed by vascular perfusion and embeded in Epon. Whole lobes were sectioned from pole to pole and slides were prepared of sections every 0.3 mm. Capillaries were clearly enlarged by 3 days and they enlarged progressively thereafter. By 3 days, the cells of many neighboring capillaries came into close apposition and from this time on, there was evidence of fusion of capillary walls in the form of partial septa in the capillary lumens. Fusion continued until 20 days, when follicles were almost completely surrounded by a continuous endothelial sheet and unfused capillary walls were separated by connective tissue. The vascular pattern around peripheral follicles changed in a way similar to interior follicles, except that in places, capillaries were gradually excluded from the space between epithelium and thyroid capsule. Vascular enlargement was restricted to the thyroid blood vessels. There was no obvious enlargement of the blood capillaries of the parathyroid despite its close proximity to the thyroid.
为研究增生性甲状腺中毛细血管的生长情况，将大鼠置于低碘饮食中，喂食含0.25%硫脲嘧啶的食物，持续100天。通过血管灌注固定甲状腺，并包埋于环氧树脂中。从甲状腺的一端到另一端对整个叶进行切片，每隔0.3毫米制备一张切片玻片。毛细血管在3天时明显增大，此后逐渐增大。到3天时，许多相邻毛细血管的细胞紧密并列，从此时起，有证据表明毛细血管壁以毛细血管腔内部分隔膜的形式融合。融合持续到20天，此时滤泡几乎完全被连续的内皮细胞层包围，未融合的毛细血管壁被结缔组织分隔。外周滤泡周围的血管模式变化方式与内部滤泡相似，只是在某些部位，毛细血管逐渐被排除在上皮与甲状腺被膜之间的间隙之外。血管增大仅限于甲状腺血管。尽管甲状旁腺与甲状腺紧邻，但其毛细血管并无明显增大。
