Anderson D E, Bagrov A Y, Austin J L
Behavioral Medicine Section, National Institute on Aging, Baltimore, Maryland 21224, USA.
Psychosom Med. 1995 Jul-Aug;57(4):373-80. doi: 10.1097/00006842-199507000-00009.
This study tested the hypothesis that breathing at the upper end of the normal range of end tidal CO2 decreases renal sodium excretion. Normotensive human subjects learned to self-regulate end tidal CO2 using a respiratory gas monitor and feedback procedure. Urine flow rates were increased by a standardized water drinking regimen. Urinary volume and sodium and potassium excretion were decreased during 30 minutes of inhibited (i.e. high normal end tidal CO2) breathing, compared with levels preceding and after task performance. Blood pressure, but not heart rate, increased during task performance. Plasma volume increase under these conditions is indicated by the observation that urinary excretion of an endogenous digoxin-like factor was increased. The physiological mechanism by which inhibited breathing elicits renal sodium retention remains to be determined. This breathing pattern could mediate the role of behavioral stress in some forms of hypertension.
在呼气末二氧化碳正常范围上限进行呼吸会减少肾钠排泄。血压正常的人类受试者通过呼吸气体监测器和反馈程序学会自我调节呼气末二氧化碳。通过标准化饮水方案增加尿流率。与任务执行前和执行后的水平相比，在抑制性（即高正常呼气末二氧化碳）呼吸的30分钟内，尿量以及钠和钾排泄量减少。任务执行期间血压升高，但心率未升高。内源性地高辛样因子尿排泄增加这一观察结果表明在这些条件下血浆量增加。抑制性呼吸引发肾钠潴留的生理机制尚待确定。这种呼吸模式可能在某些形式的高血压中介导行为应激的作用。
