Ho C S, Ho S C, Swaminathan R
Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
Int J Cardiol. 1993 Apr;39(1):1-4. doi: 10.1016/0167-5273(93)90290-w.
We examined the relationship between the excretion of electrolytes (sodium, potassium and calcium), dopamine and digoxin-like immunoreactive substance in 41 young healthy female subjects (age 18-23 years) in order to study the interaction of electrolyte intake on dopamine and digoxin-like immunoreactive substance--factors which have been postulated to have a pathogenic role in hypertension. Sodium excretion was significantly correlated with dopamine excretion (r = 0.545, P < 0.0005) and digoxin-like immunoreactive substance (r = 0.359, P < 0.02). There was also a significant correlation between calcium and digoxin-like immunoreactive substance (r = 0.345, P < 0.03). Stepwise multiple regression analysis further confirmed that sodium is the only contributor to dopamine excretion and calcium is the only contributor to digoxin-like immunoreactive substance (r2 = 0.114). We conclude that in young healthy subjects dopamine excretion is determined partly by sodium intake and that the excretion of digoxin-like immunoreactive substance is independent of sodium intake.
我们研究了41名18至23岁年轻健康女性受试者体内电解质（钠、钾和钙）、多巴胺及地高辛样免疫反应物质的排泄之间的关系，以研究电解质摄入对多巴胺和地高辛样免疫反应物质的相互作用，这些因素被认为在高血压发病中起致病作用。钠排泄与多巴胺排泄显著相关（r = 0.545，P < 0.0005）以及与地高辛样免疫反应物质显著相关（r = 0.359，P < 0.02）。钙与地高辛样免疫反应物质之间也存在显著相关性（r = 0.345，P < 0.03）。逐步多元回归分析进一步证实，钠是多巴胺排泄的唯一决定因素，钙是地高辛样免疫反应物质的唯一决定因素（r2 = 0.114）。我们得出结论，在年轻健康受试者中，多巴胺排泄部分由钠摄入决定，且地高辛样免疫反应物质的排泄与钠摄入无关。
