Perch S J, Machtay M, Markiewicz D A, Kligerman M M
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, USA.
Radiology. 1995 Dec;197(3):863-6. doi: 10.1148/radiology.197.3.7480771.
To determine whether midline mucosa-sparing blocks (MSBs) protecting the aerodigestive tract can statistically significantly reduce acute toxicity during radiation therapy for carcinoma of the head and neck, without compromising tumor control.
Radiation records and simulation films were reviewed in 125 patients with carcinoma of the oral cavity, oropharynx, or nasopharynx. Patients with and without MSBs were compared. Measures of acute toxicity during radiation therapy were weight loss (> or = 5%), hospitalization for nutritional support, and unplanned treatment interruptions (> or = 5 days). Actuarial local-regional tumor control was compared.
Patients with MSBs had significantly less weight loss (26 of 50 vs 37 of 47 patients, P = .006), fewer hospitalizations for nutritional support (one of 61 vs seven of 64 patients, P = .04), and a trend toward fewer treatment interruptions (10 of 61 vs 19 of 64 patients, P = .07) than patients without MSBs. The 3-year actuarial tumor control rates in the neck were similar.
Midline MSBs decrease acute toxicity during radiation therapy for carcinoma of the oral cavity, oropharynx, and nasopharynx without compromising tumor control.
确定保护气道消化道的中线黏膜保留阻滞（MSB）在不影响肿瘤控制的情况下，是否能在头颈部癌放射治疗期间显著降低急性毒性。
回顾了125例口腔、口咽或鼻咽癌患者的放射记录和模拟胶片。对有和没有MSB的患者进行了比较。放射治疗期间急性毒性的指标包括体重减轻（≥5%）、因营养支持住院以及计划外治疗中断（≥5天）。比较了精算局部区域肿瘤控制情况。
与没有MSB的患者相比，有MSB的患者体重减轻明显较少（50例中的26例 vs 47例中的37例，P = 0.006），因营养支持住院的次数较少（61例中的1例 vs 64例中的7例，P = 0.04），且治疗中断次数有减少趋势（61例中的10例 vs 64例中的19例，P = 0.07）。颈部的3年精算肿瘤控制率相似。
中线MSB可降低口腔、口咽和鼻咽癌放射治疗期间的急性毒性，且不影响肿瘤控制。
