Sirigu F, Capeccioni S, Dessì A, Masia A M
Cattedra di Malattie dell'Apparato Digerente, Università di Cagliari.
Riv Eur Sci Med Farmacol. 1994 Sep-Dec;16(5-6):131-4.
To investigate on the presence and significance of Helicobacter pylori (Hp) in Barrett's mucosa, esophageal biopsy specimens from 34 patients with columnar-lined epithelium were retrospectively examined. The incidence of colonization was compared with that observed in a control group of 76 subjects with normal esophageal mucosa or moderate esophagitis. Three of the 34 Barrett's specimens were Hp-positive and only 1 of these showed evidence of inflamed mucosa (p = NS). We do not find in this study any evidence to support the existence of association between Hp and Barrett's esophagus or esophageal inflammation. The presence of Hp in antral mucosa of all positive cases suggest the possibility that esophageal colonisation might merely be a consequence of reflux from the gastric antrum.
为研究幽门螺杆菌（Hp）在巴雷特黏膜中的存在情况及其意义，我们对34例柱状上皮化生患者的食管活检标本进行了回顾性检查。将Hp定植率与76例食管黏膜正常或患有中度食管炎的对照组进行了比较。34例巴雷特标本中有3例Hp呈阳性，其中仅1例有黏膜炎症迹象（p=无显著差异）。在本研究中，我们未发现任何证据支持Hp与巴雷特食管或食管炎症之间存在关联。所有阳性病例胃窦黏膜中Hp的存在提示食管定植可能仅仅是胃窦反流的结果。
