Almenar L, Montoro J, Palencia M, Puig N, Molina R, Reyes I, Chirivella M, Moreno M T, Díez J L, Algarra F
Servicio de Cardiología, Hospital Universitario La Fe, Valencia.
Rev Esp Cardiol. 1995 Oct;48(10):666-70.
The purpose of this study was to analyze the frequency of the different antigens of HLA in patients with diagnosis of very advanced dilated cardiomyopathy and ischemic heart disease by comparing them with a control group of supposedly healthy subjects.
The group of dilated cardiomyopathy consisted of 35 patients (8 women and 27 men) aged between 14 and 60 years. The group of ischemic heart disease included 32 patients (4 women and 28 men) aged between 34 and 64 years. The control group comprised 1337 subjects of the Spanish Mediterranean area, supposedly healthy and recruited from paternity studies.
In dilated cardiomyopathy we found a higher incidence in comparison with the control group of the A-2 (62.86% vs 46.22%), B-12 (60.00% vs 32.38%) and DQ-3 (82.86 vs 49.96%) antigens, and a lower incidence of B-51 (0.00% vs 12.49%). In ischemic heart disease we found, when comparing to the control group, a higher incidence of A-11 (31.25% vs 13.08%) and A-29 (34.38% vs 14.58%) antigens and a lower incidence of DQ-2 (15.63% vs 49.88%).
In the Spanish Mediterranean area, the presence of A-2, B-12 and DQ-3 antigens, as well as the absence of B-51 would favour the appearance of advanced dilated cardiomyopathy. The presence of the A-11 and A-29 antigens would predispose to ischemic cardiomyopathy while the presence of DQ-2 would have a protective effect on the appearance of this cardiopathy.
本研究的目的是通过将诊断为极重度扩张型心肌病和缺血性心脏病的患者与一组假定健康的对照组进行比较，分析人类白细胞抗原（HLA）不同抗原的出现频率。
扩张型心肌病组由35例患者组成（8名女性和27名男性），年龄在14岁至60岁之间。缺血性心脏病组包括32例患者（4名女性和28名男性），年龄在34岁至64岁之间。对照组由1337名西班牙地中海地区的受试者组成，假定健康，从亲子鉴定研究中招募。
在扩张型心肌病中，与对照组相比，我们发现A-2（62.86%对46.22%）、B-12（60.00%对32.38%）和DQ-3（82.86对49.96%）抗原的发生率较高，而B-51的发生率较低（0.00%对12.49%）。在缺血性心脏病中，与对照组相比，我们发现A-11（31.25%对13.08%）和A-29（34.38%对14.58%）抗原的发生率较高，而DQ-2的发生率较低（15.63%对49.88%）。
在西班牙地中海地区，A-2、B-12和DQ-3抗原的存在以及B-51的缺失有利于极重度扩张型心肌病的出现。A-11和A-29抗原的存在易导致缺血性心肌病，而DQ-2的存在对这种心脏病的出现具有保护作用。
