Bürgi U, Villiger L, Diem P
Departement Medizin, Inselspital Bern.
Ther Umsch. 1995 Oct;52(10):635-8.
Diabetes mellitus is associated with a number of well-known, specific macro- and microvascular as well as neuropathic complications. The typical and specific association of microvascular and neuropathic complications with diabetes suggests a causal relationship with hyperglycemia or associated metabolic abnormalities. The results of the Diabetes Control and Complications Trial (DCCT) as well as other recent studies have demonstrated that in patients with insulin-dependent diabetes mellitus (IDDM) the incidence of retinopathy, nephropathy and neuropathy can be reduced by intensive treatment. Strategies of intensified insulin therapy and the clinical importance of improved diabetic control are outlined in view of these studies.
糖尿病与许多众所周知的特定大血管和微血管以及神经病变并发症相关。微血管和神经病变并发症与糖尿病之间典型而特定的关联表明与高血糖或相关代谢异常存在因果关系。糖尿病控制与并发症试验（DCCT）以及其他近期研究的结果表明，在胰岛素依赖型糖尿病（IDDM）患者中，强化治疗可降低视网膜病变、肾病和神经病变的发生率。鉴于这些研究，概述了强化胰岛素治疗策略以及改善糖尿病控制的临床重要性。
