Hay D W, Torphy T J, Undem B J
Department of Pulmonary Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA.
Trends Pharmacol Sci. 1995 Sep;16(9):304-9. doi: 10.1016/s0165-6147(00)89059-8.
The cysteinyl leukotrienes have long been suspected to play a role in the pathogenesis of asthma. This speculation was based largely on their release in human lung following antigen challenge as well as their potent bronchoconstrictor activity. However, there is increasing evidence that the cysteinyl leukotrienes also produce several pro-inflammatory effects and alter the activity of neuronal pathways in the airways. Douglas Hay, Theodore Torphy and Bradley Undem review these recent data and discuss the therapeutic possibilities of cysteinyl leukotriene receptor antagonists and 5-lipoxygenase inhibitors.
长期以来，人们一直怀疑半胱氨酰白三烯在哮喘发病机制中起作用。这种推测主要基于它们在抗原激发后在人肺中的释放以及它们强大的支气管收缩活性。然而，越来越多的证据表明，半胱氨酰白三烯还会产生多种促炎作用，并改变气道中神经通路的活性。道格拉斯·海伊、西奥多·托尔菲和布拉德利·昂德姆回顾了这些最新数据，并讨论了半胱氨酰白三烯受体拮抗剂和5-脂氧合酶抑制剂的治疗可能性。
