Páv J
Vnitr Lek. 1995 Sep;41(9):624-8.
In the submitted review the author discusses two substances secreted into the circulation which can similarly as insulin lower the blood sugar level. These substances are IGF-I (insulin-like growth factor I) and GLP (glucagon-like peptide). While in case of the former it is not certain whether it participates in the glucose homeostasis, this is beyond doubt in the latter. IGF-I prepared by the recombinant technique can be used therapeutically in cases of insulin resistance caused by a receptor or postreceptor disorder, because it may act via its own receptor. Side-effects after larger doses are a problem. GLP-1, the use of which would be useful in type 2 diabetics as it stimulates insulin secretion, is not used so far in therapy because hitherto prepared preparations have a very short period of a effectiveness.
在提交的综述中，作者讨论了两种分泌到循环系统中的物质，它们与胰岛素类似，能够降低血糖水平。这些物质是IGF-I（胰岛素样生长因子I）和GLP（胰高血糖素样肽）。对于前者，尚不确定它是否参与葡萄糖稳态，但对于后者则毫无疑问。通过重组技术制备的IGF-I可用于治疗由受体或受体后紊乱引起的胰岛素抵抗，因为它可能通过自身受体起作用。大剂量使用后的副作用是个问题。GLP-1对2型糖尿病患者有用，因为它能刺激胰岛素分泌，但目前尚未用于治疗，因为迄今制备的制剂有效性持续时间非常短。
