Peresadin N A, Frolov V M, Pinskiĭ L L
Lik Sprava. 1995 Jan-Feb(1-2):76-9.
It has been established that in the acute period of viral hepatitis (VH) the level of chromosome aberrations is 4.4-fold and 6.6-fold that of the norm in VHA and VHB respectively, with the chromatid type aberrations predominating. Frequency of metaphases with chromosome aberrations in substantially higher in patients selected from those categories of individuals working at chemical enterprises and persons living in the zone of exposure to discharges from huge metallurgical works and coking plants. There is a correlation between the markedness of cytogenetic disturbances and degree of cellular immune deficiency. Use of antioxidants (tocopheroli acetas, parmidin, quercetin) in the complex of drug preparations contributes to the normalization of cytogenetic indices and reduction of frequency of protracted and chronic forms of hepatitis.
已经确定，在病毒性肝炎（VH）急性期，甲型肝炎（VHA）和乙型肝炎（VHB）患者的染色体畸变水平分别是正常水平的4.4倍和6.6倍，且以染色单体型畸变为主。从化工企业工作的人群以及生活在大型冶金厂和焦化厂排放物暴露区域的人群中选取的患者，出现染色体畸变的中期分裂相频率显著更高。细胞遗传学紊乱的严重程度与细胞免疫缺陷程度之间存在相关性。在药物制剂组合中使用抗氧化剂（生育酚乙酸酯、巴马亭、槲皮素）有助于细胞遗传学指标正常化，并降低迁延性和慢性肝炎的发生率。
