Erciyes N, Aktürk G, Solak M, Dohman D
Department of Anesthesiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Acta Anaesthesiol Scand. 1995 Aug;39(6):845-6. doi: 10.1111/j.1399-6576.1995.tb04182.x.
In this study we aimed to investigate clinically whether morphine acts on the peripheral nervous system directly. Twenty adult patients, who were scheduled for upper extremity surgery under tourniquet, had intravenous regional anesthesia. They were divided into two groups: one group was given 30 ml of 1% prilocaine plus 10 ml of 0.9% sodium chloride (P group) and the other group was given 30 ml of 1% prilocaine plus 6 mg morphine sulfate in 10 ml of 0.9% sodium chloride (P/M group). The onset of analgesia and anesthesia and recovery from anesthesia and analgesia were investigated in both groups. In the P/M group, the onset of analgesia and anesthesia was statistically faster and the recovery from anesthesia and analgesia was statistically slower than in the P group (P < 0.05). We conclude that morphine is clinically effective in the peripheral nervous system at this dosage range.
在本研究中，我们旨在临床研究吗啡是否直接作用于外周神经系统。20例计划在止血带下进行上肢手术的成年患者接受了静脉区域麻醉。他们被分为两组：一组给予30 ml 1%丙胺卡因加10 ml 0.9%氯化钠（P组），另一组给予30 ml 1%丙胺卡因加6 mg硫酸吗啡溶于10 ml 0.9%氯化钠中（P/M组）。观察两组镇痛和麻醉的起效时间以及麻醉和镇痛的恢复时间。在P/M组中，镇痛和麻醉的起效时间在统计学上比P组更快，而麻醉和镇痛的恢复时间在统计学上比P组更慢（P<0.05）。我们得出结论，在此剂量范围内，吗啡在外周神经系统中具有临床疗效。
