Martí-Fàbregas J, Dourado M, Sanchis J, Miralda R, Pradas J, Illa I
Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.
Acta Neurol Scand. 1995 Sep;92(3):261-4. doi: 10.1111/j.1600-0404.1995.tb01699.x.
In amyotrophic lateral sclerosis (ALS), symptoms apparently spread following regional rules, and depending on the site of onset. We examined if respiratory function deterioration appears earlier or is more severe in patients with upper-limb onset.
MATERIAL & METHODS: We compared the results of various pulmonary function tests (PFT) obtained at diagnosis depending on the site of onset in 49 ALS patients. In a longitudinal study, we compared the deterioration of forced vital capacity (FVC) in relation to the site of onset, and analyzed the time elapsed to reach values below 80% of predicted according to site of onset, and we compared the survival depending on the site of onset.
No significant differences in PFT were found in the upper-limb onset group in any of the analysis performed. No differences in survival were detected in any disease onset group.
Pulmonary function deterioration does not appear to be time-linked to arm onset in ALS.
在肌萎缩侧索硬化症（ALS）中，症状显然遵循区域规则扩散，且取决于发病部位。我们研究了上肢起病的患者呼吸功能恶化是否更早出现或更严重。
我们比较了49例ALS患者在诊断时根据发病部位获得的各种肺功能测试（PFT）结果。在一项纵向研究中，我们比较了与发病部位相关的用力肺活量（FVC）的恶化情况，并分析了根据发病部位达到预测值的80%以下所经过的时间，还比较了不同发病部位的生存率。
在上肢起病组进行的任何分析中，均未发现肺功能测试有显著差异。在任何疾病起病组中均未检测到生存率的差异。
在ALS中，肺功能恶化似乎与上肢起病没有时间关联。
