Lygre H, Solheim E, Gjerdet N R, Espelid M
Department of Dental Biomaterials, School of Dentistry, University of Bergen, Norway.
Acta Odontol Scand. 1995 Aug;53(4):249-53. doi: 10.3109/00016359509005981.
Palatal biopsy specimens were obtained from patients with denture stomatitis. The fatty acids were extracted from the tissue, then separated, identified, and quantified by a gas-chromatographic technique. The sensitivity of this method enabled analyses of specimens with a wet weight of less than 1 mg. The concentration of the fatty acids C16:1 (n-7) and C24:1 (n-9) differed significantly between samples from hyperplastic and clinically healthy tissue in the denture stomatitis patients. By comparing specimens from denture stomatitis patients and non-denture subjects, the concentration of seven fatty acids, two saturated and five unsaturated, was found to be significantly different. A multivariate data-analytical method distinguished between the fatty acid composition in specimens from denture stomatitis patients and from non-denture subjects.
从患有义齿性口炎的患者身上获取腭部活检标本。从组织中提取脂肪酸，然后通过气相色谱技术进行分离、鉴定和定量。该方法的灵敏度能够对湿重小于1毫克的标本进行分析。在义齿性口炎患者的增生组织和临床健康组织的样本中，脂肪酸C16:1（n-7）和C24:1（n-9）的浓度存在显著差异。通过比较义齿性口炎患者和无义齿受试者的标本，发现七种脂肪酸（两种饱和脂肪酸和五种不饱和脂肪酸）的浓度存在显著差异。一种多变量数据分析方法能够区分义齿性口炎患者和无义齿受试者标本中的脂肪酸组成。
