Morimoto K, Kihara A, Suetsugu T
Department of Removable Prosthodontics, Kyushu University, Fukuoka, Japan.
J Oral Rehabil. 1987 Nov;14(6):513-22. doi: 10.1111/j.1365-2842.1987.tb00747.x.
The clinical and pathological study was performed in order to determine the histopathological and cytoimmunological characteristics of denture stomatitis. All specimens were biopsy materials from seventeen patients with denture stomatitis. Normal palatal mucosae from ten patients served as the control. In addition to the usual staining methods, naphtol AS-D chloroacetate esterase stain and peroxidase-antiperoxidase method were used to detect mast cells and plasma cells. Denture stomatitis could be divided into atrophic and hyperplastic types. The former showed a smooth and atrophic mucosa. The latter showed a large number of exophytic projections which were composed of marked acanthosis and submucosal fibrosis, and was further subdivided into granular and papillary subtype according to the size of projections. In the present study, there were six cases of the atrophic type, and eleven cases of the hyperplastic type (consisting of seven granular and four papillary subtypes). The hyperplastic type was more frequently observed in patients with partial dentures compared with complete dentures and was associated frequently with ill fitting of the denture base as well as agglutination of denture plaque. Cytoimmunological study revealed that there was a pronounced increase of plasma cells, especially IgG- and IgA-producing cells, and a moderate increase of lymphocytes as well as mast cells in both types of denture stomatitis. Mast cells were always noted in the area with marked plasma cell infiltration, suggesting an intimate relation between both cells. These findings suggest that the immunological reactions play some role in the pathogenesis of denture stomatitis.
为确定义齿性口炎的组织病理学和细胞免疫学特征，进行了临床和病理研究。所有标本均取自17例义齿性口炎患者的活检材料。10例患者的正常腭黏膜作为对照。除常规染色方法外，还采用萘酚AS-D氯乙酸酯酶染色和过氧化物酶-抗过氧化物酶法检测肥大细胞和浆细胞。义齿性口炎可分为萎缩型和增生型。前者表现为黏膜光滑萎缩。后者表现为大量外生性突起，由明显的棘层肥厚和黏膜下纤维化组成，并根据突起大小进一步细分为颗粒型和乳头型亚型。在本研究中，萎缩型有6例，增生型有11例（包括7例颗粒型和4例乳头型亚型）。与全口义齿相比，增生型在局部义齿患者中更常见，且常与义齿基托不合适以及义齿菌斑凝集有关。细胞免疫学研究显示，在两种类型的义齿性口炎中，浆细胞尤其是产生IgG和IgA的细胞明显增多，淋巴细胞和肥大细胞中度增多。肥大细胞总是出现在浆细胞明显浸润的区域，提示两种细胞之间存在密切关系。这些发现表明免疫反应在义齿性口炎的发病机制中起一定作用。
