Cimino A, Speciale R, Gallina S, Cimino M, Cimino G, De Feo G, Aragona F
Clinica Otorinolaringoiatrica Base, Università di Palermo.
Acta Otorhinolaryngol Ital. 1995 Apr;15(2 Suppl 47):18-23.
In order to clarify pathogenesis of Obstructive Sleep Apnea Syndrome (OSAS) in patients with anatomic abnormalities of upper airways, we studied soft palate and uvula of OSAS patients by means of histological and ultrastructural techniques. 38 OSAS patients, severe and moderately severe form, underwent modified Palatopharingoplasty. We evaluated only 16 OSAS patients' soft palate and uvula and observed histological changes in all of them: submucosal edema and minor salivary glandes ipertrophy and iperplasy are present. On the contrary, ultramicroscope showed normal muscle fibers. Strie Z alterations and sarcomeres disorganization, although present, have no statistical value. Very probably, ronflement and apneas determined the observed alterations through trauma on pharingeal wall. Therefore, they are not OSAS primary cause.
为了阐明上气道解剖结构异常的阻塞性睡眠呼吸暂停综合征（OSAS）患者的发病机制，我们采用组织学和超微结构技术研究了OSAS患者的软腭和悬雍垂。38例重度和中度重度OSAS患者接受了改良腭咽成形术。我们仅评估了16例OSAS患者的软腭和悬雍垂，并观察到他们所有人都有组织学变化：存在粘膜下水肿以及小唾液腺肥大和增生。相反，超显微镜显示肌纤维正常。虽然存在Z线改变和肌节紊乱，但无统计学意义。很可能，鼾声和呼吸暂停是通过对咽壁的创伤导致了观察到的改变。因此，它们不是OSAS的主要原因。
