Sandholm M, Vidovic A, Puotunen-Reinert A, Sankari S, Nyholm K, Rita H
Department of Clinical Sciences, College of Veterinary Medicine, Helsinki, Finland.
Acta Vet Scand. 1995;36(2):255-72. doi: 10.1186/BF03547694.
The discriminating ability of 15 parameters alone or in combinations, including results from analysis of plasma endotoxin, the Nycomed plasma D-Dimer test and phospholipase A2, were analyzed to predict morbidity and mortality in equine gastrointestinal colic. Endotoxaemia was a characteristic feature of the colic horses. The problem of adequately predicting nonsurvivors among colic horses required several parameters to be included in the logistic model: if the "classical parameters", (heart rate, respiratory rate, PCV, anion gap) were included in the model, addition of plasma D-dimer, phospholipase A2, and Cl- significantly improved the predictive value of the logistic model. Increasing heart rate and D-dimer together with decreasing chloride was a risk factor for nonsurvival. The sensitivity of this three-parameter logistic model to predict nonsurvival was 78% and specificity 77%. The Nycomed D-Dimer test is recommended as a horse-site test to predict disseminated intravascular coagulation and nonsurvival in equine colic.
单独或组合分析15项参数（包括血浆内毒素分析结果、Nycomed血浆D - 二聚体检测和磷脂酶A2）的鉴别能力，以预测马属动物胃肠绞痛的发病率和死亡率。内毒素血症是绞痛马匹的一个特征。要在绞痛马匹中充分预测非存活者的问题，需要在逻辑模型中纳入几个参数：如果将“经典参数”（心率、呼吸频率、红细胞压积、阴离子间隙）纳入模型，添加血浆D - 二聚体、磷脂酶A2和氯离子可显著提高逻辑模型的预测价值。心率增加、D - 二聚体增加以及氯离子降低是死亡的危险因素。这个三参数逻辑模型预测死亡的敏感性为78%，特异性为77%。建议将Nycomed D - 二聚体检测作为一种现场检测方法，用于预测马属动物绞痛中的弥散性血管内凝血和死亡情况。
