Pezzi J S, Shiau Y F
Lexington Clinic, Kentucky, USA.
Am Fam Physician. 1995 Nov 1;52(6):1717-24, 1729.
Helicobacter pylori infection is quite common. In the United States, prevalence varies considerably with race, nationality, socio-economic status and location of residence. In Western countries, the prevalence of the infection has shown a steady increase with increasing age. H. pylori has been shown to cause chronic gastritis. Most patients infected with H. pylori are asymptomatic and require no therapy. The precise role of the infection in the pathogenesis of peptic ulcer disease is unknown. However, H. pylori infection is associated with a high recurrence rate of both gastric and duodenal ulcers. Eradication of the infection reduces the recurrence rate. Once H. pylori infection is acquired, it usually persists for years, possibly for the patient's lifetime. Although a causative role in gastric cancer has not been proved, evidence suggests an association between H. pylori infection and well-differentiated gastric adenocarcinoma and gastric lymphoma.
幽门螺杆菌感染相当常见。在美国，其感染率因种族、国籍、社会经济地位和居住地点的不同而有很大差异。在西方国家，该感染的发生率随年龄增长呈稳步上升趋势。幽门螺杆菌已被证实可引发慢性胃炎。大多数感染幽门螺杆菌的患者没有症状，无需治疗。该感染在消化性溃疡病发病机制中的确切作用尚不清楚。然而，幽门螺杆菌感染与胃溃疡和十二指肠溃疡的高复发率相关。根除该感染可降低复发率。一旦感染幽门螺杆菌，通常会持续数年，甚至可能终生存在。虽然幽门螺杆菌在胃癌中的致病作用尚未得到证实，但有证据表明幽门螺杆菌感染与高分化胃腺癌和胃淋巴瘤之间存在关联。
