原发性干燥综合征中的自身免疫性甲状腺疾病

Autoimmune thyroid disease in primary Sjögren's syndrome.

作者信息

Pérez B, Kraus A, López G, Cifuentes M, Alarcón-Segovia D

机构信息

Department of Nuclear Medicine, Instituto Nacional de la Nutrición Salvador Zubirán, Tlalpan, Mexico.

出版信息

Am J Med. 1995 Nov;99(5):480-4. doi: 10.1016/s0002-9343(99)80223-x.

DOI:10.1016/s0002-9343(99)80223-x

PMID:7485204

Abstract

PURPOSE

To evaluate the prevalence of autoimmune thyroid disease and thyroid dysfunction in patients with primary Sjögren's syndrome.

PATIENTS AND METHODS

Thyroid function of 33 patients with primary Sjögren's syndrome was clinically and biochemically evaluated. Thyroid hormones and autoantibodies against thyroid peroxidase, thyroglobulin, and thyroid hormones were measured.

RESULTS

Autoimmune thyroid disease and thyroid dysfunction were found in 15 cases (45%): autoimmune thyroiditis in 8 (24%); autoimmune hyperthyroidism in 2 (6%); and reversible iodine-induced hypothyroidism in the remaining 5 (15%). One or more of the evaluated autoantibodies were detected in 8 euthyroid patients (24%). Overall, the prevalence of autoantibodies against thyroid peroxidase, thyroglobulin, thyroxine, and triiodothyronine was 45%, 18%, 42%, and 36%, respectively.

CONCLUSIONS

The high prevalence of autoimmune thyroid disease and thyroid dysfunction found in primary Sjögren's syndrome, using sensitive immunologic and thyroid function tests, suggest that both diseases are more frequently associated than it was previously thought, and should be sought clinically and by laboratory tests in all patients with primary Sjögren's syndrome.

摘要

目的

评估原发性干燥综合征患者自身免疫性甲状腺疾病及甲状腺功能障碍的患病率。

患者与方法

对33例原发性干燥综合征患者的甲状腺功能进行临床及生化评估。检测甲状腺激素以及抗甲状腺过氧化物酶、甲状腺球蛋白和甲状腺激素的自身抗体。

结果

15例（45%）患者存在自身免疫性甲状腺疾病及甲状腺功能障碍：8例（24%）为自身免疫性甲状腺炎；2例（6%）为自身免疫性甲状腺功能亢进；其余5例（15%）为可逆性碘致甲状腺功能减退。8例甲状腺功能正常的患者（24%）检测到一种或多种所评估的自身抗体。总体而言，抗甲状腺过氧化物酶、甲状腺球蛋白、甲状腺素和三碘甲状腺原氨酸自身抗体的患病率分别为45%、18%、42%和36%。