Baldini Chiara, Ferro Francesco, Mosca Marta, Fallahi Poupak, Antonelli Alessandro
Rheumatology Unit, University of Pisa, Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Front Endocrinol (Lausanne). 2018 Apr 3;9:121. doi: 10.3389/fendo.2018.00121. eCollection 2018.
Sjögren's syndrome (SS) and autoimmune thyroid diseases (AITD) may frequently coexist in clinical practice, resulting in a complex overlapping disorder that represents a particular example of the expression of heterogeneity in patients with autoimmune disorders. Objective of this review was to describe the prevalence of the SS-AITD association in the most recent literature, exploring in particular to what extent the presence of AITD might influence the clinical expression of SS and . Moreover, we summarized some of the proposed genetic, biologic, and molecular mechanisms implied in the pathogenesis of AITD-SS association. Finally, we explored risk factors for lymphoma development in both AITD and SS. We performed a Medline search of English language articles published in the PubMed database in order to provide a critical overview of the recent literature on pathogenesis and clinical features of AITD-SS overlapping disease. All the articles were critically analyzed to select the most relevant contributions.
干燥综合征（SS）与自身免疫性甲状腺疾病（AITD）在临床实践中可能经常并存，导致一种复杂的重叠性疾病，这是自身免疫性疾病患者异质性表现的一个特殊例子。本综述的目的是描述最新文献中SS-AITD关联的患病率，特别探讨AITD的存在在多大程度上可能影响SS的临床表型。此外，我们总结了一些关于AITD-SS关联发病机制中所涉及的遗传、生物学和分子机制。最后，我们探讨了AITD和SS中淋巴瘤发生的危险因素。我们在PubMed数据库中对发表的英文文章进行了Medline检索，以便对AITD-SS重叠疾病的发病机制和临床特征的最新文献进行批判性综述。对所有文章进行了批判性分析，以选择最相关的研究成果。
