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Why is the reproductive performance lower in Becker (BMD) as compared to limb girdle (LGMD) muscular dystrophy male patients?

作者信息

Eggers S, Lauriano V, Melo M, Takata R I, Akiyama J, Passos-Bueno M R, Gentil V, Frota-Pessoa O, Zatz M

机构信息

Departamento de Biologia, Universidade de São Paulo, Brazil.

出版信息

Am J Med Genet. 1995 Feb 27;60(1):27-32. doi: 10.1002/ajmg.1320600106.

Abstract

We had previously reported that patients affected with BMD have a significantly reduced reproductive performance (f = 0.12) as compared to male LGMD patients of similar age and physical impairment (f = 0.98). In the present study parameters such as the socio-economic level, as well as psychosocial, intellectual, and psychiatric functionings could not explain the low fitness of BMD patients. The effect of genetic counseling, a greater difficulty in coping with the disease, and relating to women and/or a potential malfunction of reproductive physiology are discussed as possible causes.

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