No evidence for allelic association between bipolar disorder and monoamine oxidase A gene polymorphisms.

作者信息

Craddock N, Daniels J, Roberts E, Rees M, McGuffin P, Owen M J

机构信息

Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom.

出版信息

Am J Med Genet. 1995 Aug 14;60(4):322-4. doi: 10.1002/ajmg.1320600412.

We have tested the hypothesis that DNA markers in the MAOA gene show allelic association with bipolar affective disorder. Eighty-four unrelated Caucasian patients with DSM III-R bipolar disorder and 84 Caucasian controls were typed for three markers in MAOA: a dinucleotide repeat in intron 2, a VNTR in intron 1, and an Fnu4HI RFLP in exon 8. No evidence for allelic association was observed between any of the markers and bipolar disorder.