Tissot S, Normand S, Khalfallah Y, Delafosse B, Viale J P, Annat G, Motin J, Riou J P
Service d'Anesthésie-Réanimation, Hôpital Edouard Herriot, Lyon, France.
Am J Physiol. 1995 Oct;269(4 Pt 1):E753-8. doi: 10.1152/ajpendo.1995.269.4.E753.
The effects of lipid administration on carbohydrate oxidation rate remain controversial, particularly in critically ill patients. The aim of this study was to determine the effects of these patients of a continuous lipid infusion on glucose metabolism using indirect calorimetry and stable isotopes. We studied seven patients, mechanically ventilated, during two consecutive 24-h periods. Throughout the first period they received a continuous infusion of glucose (2 mg.kg-1.min-1) and amino acids. During the second period, in addition to the glucose, they received a continuous infusion of 1 mg.kg-1.min-1 of long-chain triglycerides emulsion. Substrate oxidation rates were calculated from pulmonary gas exchange and nitrogen excretion measurements. Glucose kinetic parameters were measured using primed constant infusions of [6,6-2H2]glucose and [1-13C]glucose. The lipid infusion did not modify the glucose metabolism parameters; 45% of the lipid supply was stored.
