Bingaman E W, Van de Kar L D, Yracheta J M, Li Q, Gray T S
Department of Cell Biology, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA.
Am J Physiol. 1995 Oct;269(4 Pt 2):R856-63. doi: 10.1152/ajpregu.1995.269.4.R856.
The purpose of this study was to examine the effect of circulating androgens on neuroendocrine, autonomic, and behavioral responses to stress. The effects of conditioned stress were studied in male Sprague-Dawley rats that were intact, gonadectomized, or gonadectomized and treated with dihydrotestosterone (DHT). Intact animals received sham surgeries. Animals were stressed 3 wk after surgery. The adrenocorticotropic hormone (ACTH) response to conditioned stress was significantly potentiated (P < 0.01) in gonadectomized males compared with sham-operated and gonadectomized DHT-treated animals. In stressed rats, plasma corticosterone levels were significantly higher (P < 0.05) in gonadectomized animals compared with DHT-treated castrates. The prolactin response to stress was decreased (P < 0.01) in gonadectomized males compared with sham-operated and gonadectomized DHT-treated rats. The stress-induced increases in plasma renin activity and concentration were not altered in gonadectomized or in gonadectomized DHT-treated animals. Nonstressed DHT-treated castrates exhibited more "fearlike" behavior compared with nonstressed sham-operated and gonadectomized animals. However, conditioned stress produced the same behavioral effects in all treatment groups. The results demonstrate that the ACTH/corticosterone, prolactin, and behavioral responses to a psychological stressor are differentially regulated by circulating androgens.
本研究的目的是检验循环雄激素对神经内分泌、自主神经以及应激行为反应的影响。在完整、去势或去势并用二氢睾酮（DHT）处理的雄性斯普拉格-道利大鼠中研究条件性应激的影响。完整动物接受假手术。动物在手术后3周接受应激处理。与假手术和去势并用DHT处理的动物相比，去势雄性动物对条件性应激的促肾上腺皮质激素（ACTH）反应显著增强（P<0.01）。在应激大鼠中，与用DHT处理的去势动物相比，去势动物的血浆皮质酮水平显著更高（P<0.05）。与假手术和去势并用DHT处理的大鼠相比，去势雄性动物对应激的催乳素反应降低（P<0.01）。在去势或去势并用DHT处理的动物中，应激诱导的血浆肾素活性和浓度增加未发生改变。与未应激的假手术和去势动物相比，未应激的用DHT处理的去势动物表现出更多“恐惧样”行为。然而，条件性应激在所有处理组中产生相同的行为效应。结果表明，ACTH/皮质酮、催乳素以及对心理应激源的行为反应受循环雄激素的差异性调节。
