Gray T S, Piechowski R A, Yracheta J M, Rittenhouse P A, Bethea C L, Van de Kar L D
Department of Cell Biology, Loyola Stritch School of Medicine, Maywood, Ill 60153.
Neuroendocrinology. 1993 Mar;57(3):517-24. doi: 10.1159/000126400.
The contribution of the bed nucleus of the stria terminalis (BST) to the expression of stress-induced increases in ACTH/corticosterone, prolactin and renin secretion was assessed. Neurons in the lateral part of the BST were destroyed with bilateral injections of the cell-selective neurotoxin ibotenic acid (1.5 micrograms in 0.1 microliter of solution per side). Two weeks later, the rats were stressed using an immobilization or conditioned stress paradigm. Rats with lesions in the lateral part of the BST showed attenuated ACTH and corticosterone responses to conditioned stress. Bilateral ablation of lateral BST significantly reduced the prolactin secretory response to conditioned stress. The same lesions had no effect upon plasma increases in renin that occur in response to conditioned stress. Also, destruction of neurons in the BST did not affect immobilization-induced increases in ACTH, corticosterone, prolactin or renin. Previous studies have demonstrated that ibotenic acid lesions in the central amygdala reduce corticosterone and renin response to conditioned stress. Thus, both the BST and central amygdala are important for the adrenocortical response to conditioned stress. Neurons in the central nucleus of the amygdala are part of the circuitry that mediates renin responses to conditioned stress. Neurons in the BST are important for the full expression of prolactin responses to conditioned stress. The neuronal circuitry and stressor specificity in the mediation of prolactin, renin and ACTH/corticosterone responses are discussed.
评估了终纹床核（BST）对压力诱导的促肾上腺皮质激素/皮质酮、催乳素和肾素分泌增加的表达的贡献。通过双侧注射细胞选择性神经毒素鹅膏蕈氨酸（每侧0.1微升溶液中含1.5微克）破坏BST外侧部分的神经元。两周后，使用固定或条件性应激范式对大鼠施加应激。BST外侧部分有损伤的大鼠对条件性应激的促肾上腺皮质激素和皮质酮反应减弱。双侧切除BST外侧部分显著降低了对条件性应激的催乳素分泌反应。相同的损伤对因条件性应激而出现的血浆肾素升高没有影响。此外，破坏BST中的神经元并不影响固定诱导的促肾上腺皮质激素、皮质酮、催乳素或肾素的增加。先前的研究表明，中央杏仁核中的鹅膏蕈氨酸损伤会降低对条件性应激的皮质酮和肾素反应。因此，BST和中央杏仁核对于对条件性应激的肾上腺皮质反应都很重要。杏仁核中央核中的神经元是介导对条件性应激的肾素反应的神经回路的一部分。BST中的神经元对于催乳素对条件性应激反应的充分表达很重要。讨论了催乳素、肾素和促肾上腺皮质激素/皮质酮反应介导中的神经回路和应激源特异性。
