Johnson D, Eppler J, Giesbrecht E, Verjee Z, Rais A, Wiggins T, Fraga C, Ito S
Division of Clinical Pharmacology, Hospital for Sick Children, University of Toronto, Ontario.
Ann Emerg Med. 1995 Nov;26(5):569-74. doi: 10.1016/s0196-0644(95)70006-4.
To study the effect of multiple-dose activated charcoal (MDAC) on salicylate clearance in pigs given high-dose i.v. aspirin.
In a crossover design, six fasted pigs received 300 mg/kg i.v. aspirin followed by no treatment or MDAC (1 g/kg hourly for 6 doses by gastrostomy). Serum salicylate samples were obtained every 30 minutes for 6 hours.
The mean peak salicylate concentrations were 47.4 +/- 6.2 mg/dL and 48.4 +/- 3.9 mg/dL (P = .74), and the areas under the time-serum salicylate concentration curve over 6 hours were 171,000 +/- 24,000 mg.minute/L and 188,000 +/- 18,000 mg.minute/L for the control and treatment arms, respectively (P = .22). This study had a 90% power to detect a 30% difference between arms.
MDAC does not enhance the clearance of salicylate after administration of high-dose i.v. aspirin.
研究多次剂量活性炭（MDAC）对大剂量静脉注射阿司匹林的猪体内水杨酸盐清除率的影响。
采用交叉设计，六只禁食猪静脉注射300mg/kg阿司匹林，随后不进行治疗或通过胃造口术给予MDAC（每小时1g/kg，共6剂）。每30分钟采集血清水杨酸盐样本，持续6小时。
水杨酸盐平均峰值浓度分别为47.4±6.2mg/dL和48.4±3.9mg/dL（P = 0.74），对照组和治疗组6小时内血清水杨酸盐浓度-时间曲线下面积分别为171,000±24,000mg·分钟/L和188,000±18,000mg·分钟/L（P = 0.22）。本研究有90%的把握检测出两组之间30%的差异。
大剂量静脉注射阿司匹林后，MDAC不会提高水杨酸盐的清除率。
