Wilson W B, Prochoda M
Department of Ophthalmology, University of Colorado Health Sciences Center, Denver, USA.
Arch Ophthalmol. 1995 Nov;113(11):1420-5. doi: 10.1001/archopht.1995.01100110080029.
To investigate the effects of radiotherapy on the restrictive ophthalmopathy and strabismus that occur with Graves' orbitopathy.
A prospective study of patients with motility disturbances due to thyroid orbitopathy, followed by serial quantitative measurements of ocular restrictions and deviations, both before and at 1 and 6 months after treatment with high-energy radiotherapy.
Urban subspecialty private practice.
Thirty-three consecutive patients with restricted extraocular movements and diplopia secondary to thyroid orbitopathy who were treated with radiotherapy were seen during an 8-year period.
Maximal horizontal and vertical ductions, plus ocular deviations in primary and reading positions of gaze, were quantitatively evaluated by one clinical investigator to ensure consistency.
Statistically significant improvement in gaze restriction on supraduction and improvement of vertical and horizontal strabismus were demonstrated at follow-up visits after treatment.
Although statistically significant improvement of motility disturbances were demonstrated after radiotherapy, there was less than desirable functional improvement of restrictive ophthalmopathy and strabismus; thus the usefulness of radiotherapy was limited when it was used alone to treat diplopia.
探讨放射治疗对格雷夫斯眼眶病所致限制性眼病和斜视的影响。
对因甲状腺眼眶病导致眼球运动障碍的患者进行前瞻性研究，在高能放射治疗前、治疗后1个月和6个月对眼部限制和偏斜进行系列定量测量。
城市专科私人诊所。
在8年期间，连续33例因甲状腺眼眶病继发眼球运动受限和复视而接受放射治疗的患者。
由一名临床研究人员对最大水平和垂直转位以及在第一眼位和阅读眼位时的眼位偏斜进行定量评估，以确保一致性。
治疗后的随访显示，上转时凝视受限有统计学意义的改善，垂直和水平斜视也有所改善。
虽然放射治疗后眼球运动障碍有统计学意义的改善，但限制性眼病和斜视的功能改善未达理想程度；因此，单独使用放射治疗来治疗复视时，其效用有限。
