Transitional cell carcinoma: circulating tumor antigen correlated with presence/absence of tumor (leukocyte migration assay).

Sera from patients with TCC of the urinary bladder have been fractionated. We tested the fractions for activity in the leukocyte migration test, using peripheral blood leukocytes from TCC patients, other cancer patients, and healthy control donors as indicator cells. The results suggest that an antigen associated with TCC can be detected in the sera of patients bearing TCC but not in tumor-free individuals.