Skeath J B
Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA.
Bioessays. 1995 Oct;17(10):829-31. doi: 10.1002/bies.950171002.
The development of vertebrate and invertebrate nervous systems requires the production of thousands to millions of uniquely specified neurons from progenitor neural stem cells. A central question focuses on the elucidation of the developmental mechanisms that function within neural stem cell lineages to impart unique identities to neurons. A recent report details the roles that two genes, pdm-1 and pdm-2, play within an identified neural stem cell lineage in the Drosophila embryonic central nervous system. The results show that pdm-1 and pdm-2 are coexpressed in an identified neural precursor and function redundantly to specify the fate of this cell. As such this report offers an initial view of the genetic programs that create neural diversity.
脊椎动物和无脊椎动物神经系统的发育需要祖神经干细胞产生数千到数百万个具有独特特征的神经元。一个核心问题聚焦于阐明在神经干细胞谱系中发挥作用以赋予神经元独特身份的发育机制。最近的一份报告详细阐述了两个基因，即pdm - 1和pdm - 2，在果蝇胚胎中枢神经系统中一个已确定的神经干细胞谱系中所起的作用。结果表明，pdm - 1和pdm - 2在一个已确定的神经前体细胞中共表达，并发挥冗余功能来确定该细胞的命运。因此，这份报告提供了关于产生神经多样性的遗传程序的初步观点。
