Schubert D, Chevion M
Salk Institute, La Jolla, California 92037, USA.
Biochem Biophys Res Commun. 1995 Nov 13;216(2):702-7. doi: 10.1006/bbrc.1995.2678.
There is evidence that oxidative damage plays a causative role in Alzheimer's disease and amyloid beta protein (A beta) toxicity. Iron is frequently a potent facilitator of free radical production due to its ability to mediate the conversion of H2O2 to hydroxyl radicals via the Fenton reaction or by virtue of hypervalent iron compounds. It is shown here that iron facilitates A beta toxicity to cultured cells.
有证据表明氧化损伤在阿尔茨海默病及β淀粉样蛋白（Aβ）毒性中起致病作用。铁常常是自由基产生的有力促进剂，这是由于它能够通过芬顿反应介导过氧化氢转化为羟基自由基，或者借助高价铁化合物。本文表明铁会促进Aβ对培养细胞的毒性作用。
