[2'-脱氧腺苷核苷酸的膦酰基无环类似物的合成及某些生化性质]

[Synthesis and some biochemical properties of phosphonyl acyclic analogs of 2'-deoxyadenosine nucleotides].

作者信息

Malakhov D V, Semizarov D G, Ias'ko M V

出版信息

Bioorg Khim. 1995 Jul;21(7):539-44.

Abstract

9-[2-(phosphonomethylcarbonylamino)ethyl]adenine, 9-[(2-phosphonoethyl)aminocarbonylmethyl]adenine, 9-[2-[(2-phosphonoethyl)carbonylamino]ethyl]adenine, and their diphosphates were synthesized. All three diphosphates were shown to incorporate into the 3'-terminus of the DNA chain during the synthesis of the avian myeloblastosis virus catalyzed by reverse transcriptase. However, they do not serve as substrates for DNA polymerase alpha from human placenta, polymerase beta from calf thymus, or terminal deoxynucleotidyl transferase from calf thymus.

摘要

合成了9-[2-(膦酰甲基羰基氨基)乙基]腺嘌呤、9-[(2-膦酰乙基)氨基羰基甲基]腺嘌呤、9-[2-[(2-膦酰乙基)羰基氨基]乙基]腺嘌呤及其二磷酸酯。在禽成髓细胞瘤病毒逆转录酶催化的合成过程中，所有三种二磷酸酯均显示可掺入DNA链的3'-末端。然而，它们并不是来自人胎盘的DNA聚合酶α、来自小牛胸腺的聚合酶β或来自小牛胸腺的末端脱氧核苷酸转移酶的底物。

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引用本文的文献

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2'-Deoxynucleoside 5'-triphosphates modified at alpha-, beta- and gamma-phosphates as substrates for DNA polymerases.在α、β和γ磷酸处修饰的2'-脱氧核苷5'-三磷酸作为DNA聚合酶的底物。

Nucleic Acids Res. 1998 Feb 1;26(3):778-86. doi: 10.1093/nar/26.3.778.

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