Wagemaker G
Institute of Hematology, Erasmus Universiteit Rotterdam, The Netherlands.
Stem Cells. 1995 May;13 Suppl 1:257-60. doi: 10.1002/stem.5530130731.
Immature hemopoietic cells are heterogeneous with respect to repopulating capacity following exposure to ionizing radiation, growth factor receptor and surface marker phenotype as well as cycling state. In the present paper, the evidence from studies in subhuman primates and mice is reviewed, which demonstrates that the heterogeneity of immature stem cells is also reflected by a differential sensitivity to radiation, the most immature stem cells with long-term repopulating capacity being less sensitive to radiation than assumed on the basis of 50% lethal dose (LD50) data, and the radiation sensitivity of immature hemopoietic cells measured by the spleen-colony test. In addition, these immature cells appear to have a considerable repair capacity. These findings have a direct bearing on future strategies for the treatment of patients after accidental exposure to ionizing radiation, either by transplantation of (subsets of) stem cells or by administration of a specific combination of hemopoietic growth factors.
未成熟造血细胞在受到电离辐射后，其在再增殖能力、生长因子受体和表面标志物表型以及细胞周期状态方面具有异质性。在本文中，我们综述了来自非人灵长类动物和小鼠研究的证据，这些证据表明未成熟干细胞的异质性也体现在对辐射的不同敏感性上，具有长期再增殖能力的最不成熟干细胞对辐射的敏感性低于根据50%致死剂量（LD50）数据和通过脾集落试验测得的未成熟造血细胞辐射敏感性所假设的情况。此外，这些未成熟细胞似乎具有相当强的修复能力。这些发现对于意外暴露于电离辐射后的患者的未来治疗策略具有直接影响，无论是通过干细胞（亚群）移植还是通过给予特定组合的造血生长因子。
