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[体外γ射线照射人淋巴细胞时稳定和不稳定染色体畸变频率的比较研究]

[A comparative study of the frequency of stable and unstable chromosome aberrations in the gamma irradiation of human lymphocytes in vitro].

作者信息

Sevan'kaev A V, Ankina M A, Zavitaeva T A, Zhloba A A, Golub E V, Epifanova N V, Kozlov V M, Mikhaĭlova G F, Moiseenko V V, Pozdyshkina O V

出版信息

Radiats Biol Radioecol. 1995 Sep-Oct;35(5):611-8.

PMID:7489091
Abstract

Comparative studies of the yield of stable and unstable chromosome aberrations have been carried out in human lymphocytes gamma irradiated in vitro within the doze range 0.1--1.0 Gy. It was observed that the yield of unstable chromosome aberrations (dicentrics and centric rings) is satisfactorily described for discovered dose range with linear-quadratic approximation. For stable chromosome aberrations in G-banded chromosome the dose response dependence was less expressed. The studies revealed non-random involvement of different chromosomes in translocations, and the most frequently involved are 1 and 13 chromosomes.

摘要

对体外γ射线照射剂量范围为0.1 - 1.0 Gy的人淋巴细胞中稳定和不稳定染色体畸变的产额进行了比较研究。观察到,在发现的剂量范围内,不稳定染色体畸变(双着丝粒和着丝粒环)的产额用线性二次近似法能得到满意的描述。对于G带染色体中的稳定染色体畸变,剂量反应依赖性表现较弱。研究揭示了不同染色体在易位中存在非随机参与情况,其中最常涉及的是1号和13号染色体。

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