[亚抑菌浓度的诺氟沙星、红霉素和罗红霉素对铜绿假单胞菌毒力因子的影响]
[The effect of subinhibitory concentrations of norfloxacin, erythromycin and roxithromycin on Pseudomonas aeruginosa virulence factors].
作者信息
Hostacká A
机构信息
Ustav preventívnej a klinickej medicińy, Bratislava.
出版信息
Epidemiol Mikrobiol Imunol. 1995 Sep;44(3):115-7.
PMID:7489133
Abstract
The effect of sub-MICs (1/4 MIC, 1/8 MIC, 1/16 MIC) of norfloxacin, erythromycin, roxithromycin on Pseudomonas aeruginosa virulence factors was studied. It was found that 1/4 of the MIC of norfloxacin inhibited most effectively elastase as well as proteinase activity (to 30.1% or 29.2% of the control values). Macrolide antibiotics did not reduce the tested enzymic activities but caused their increase.
摘要
研究了诺氟沙星、红霉素、罗红霉素的亚抑菌浓度（1/4 MIC、1/8 MIC、1/16 MIC）对铜绿假单胞菌毒力因子的影响。结果发现，诺氟沙星的1/4 MIC最有效地抑制了弹性蛋白酶和蛋白酶活性（降至对照值的30.1%或29.2%）。大环内酯类抗生素并未降低所检测的酶活性，反而使其升高。
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