Green S E, Chapman P D, Burn J, Bishop D T, Varma J S
Department of Surgery, University of Newcastle Upon Tyne, UK.
Br J Surg. 1995 Oct;82(10):1338-40. doi: 10.1002/bjs.1800821013.
Sixty-one asymptomatic individuals with an affected first-degree relative from five large hereditary non-polyposis colorectal cancer (HNPCC) kindreds were screened by colonoscopy. Neoplasms were found in nine (15 per cent) of 61 individuals on the first screen. Five subjects had a single adenoma while two had two adenomas each. There were two patients (3 per cent) with malignant neoplasms: one with a Dukes B adenocarcinoma and one with synchronous Dukes C adenocarcinomas in the caecum and ascending colon. These findings support the hypothesis that adenomas do not occur in large numbers in HNPCC families but, because of the high malignant conversion rate, biennial colonoscopy with removal of polyps seen is recommended.
对来自五个大型遗传性非息肉病性结直肠癌（HNPCC）家族且有一位患病一级亲属的61名无症状个体进行了结肠镜筛查。在首次筛查的61名个体中，有9名（15%）发现了肿瘤。5名受试者有一个腺瘤，2名受试者各有两个腺瘤。有2名患者（3%）患有恶性肿瘤：一名患有Dukes B期腺癌，一名在盲肠和升结肠患有同步Dukes C期腺癌。这些发现支持了以下假设，即腺瘤在HNPCC家族中不会大量出现，但由于恶性转化率高，建议每两年进行一次结肠镜检查并切除所见息肉。
