[血清素和苹果酸苄肼对大鼠心脏和肝脏线粒体谷胱甘肽过氧化物酶及脂质过氧化的影响]
[Effect of serotonin and malate benzyl hydrazine on glutathione peroxidase and lipid peroxidation by rat heart and liver mitochondria].
作者信息
Utno L Ia, Lipsberga Z E, Silova A A, Korzan V A
出版信息
Prikl Biokhim Mikrobiol. 1978 Nov-Dec;14(6):910-4.
The effect of serotonin and malate benzyl hydrazine (inhibitor MAO) on the activity of glutathione peroxidase and intensity of ascorbate-dependent peroxidation of lipids in mitochondria was investigated. Serotonin injected intraperitoneally at a concentration of 20 m/kg increased activity of glutathione peroxidase in liver mitochondria and nonfermented ascorbate-dependent peroxidation of lipids in heart mitochondria. In experiments in vitro serotonin and malate benzyl hydrazine decreased activity of glutathione peroxidase an inhibited nonfermented ascorbate-dependent peroxidation in mitochondria of the heart and liver of rats.
研究了血清素和苹果酸苄肼（单胺氧化酶抑制剂）对线粒体中谷胱甘肽过氧化物酶活性以及脂质的抗坏血酸依赖性过氧化强度的影响。以20 m/kg的浓度腹腔注射血清素可增加肝脏线粒体中谷胱甘肽过氧化物酶的活性以及心脏线粒体中脂质的非发酵抗坏血酸依赖性过氧化。在体外实验中，血清素和苹果酸苄肼降低了大鼠心脏和肝脏线粒体中谷胱甘肽过氧化物酶的活性，并抑制了脂质的非发酵抗坏血酸依赖性过氧化。
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