Amadori A, Zamarchi R, De Silvestro G, Forza G, Cavatton G, Danieli G A, Clementi M, Chieco-Bianchi L
Institute of Oncology, Interuniversity Center for Research on Cancer, University of Padova, Italy.
Nat Med. 1995 Dec;1(12):1279-83. doi: 10.1038/nm1295-1279.
We studied the genetic pattern of inheritance of the ratio between circulating CD4+ and CD8+ T lymphocytes in a population of healthy donors. The distribution of the CD4/CD8 ratio in males and females was significantly different and was significantly affected by age. In 46 randomly selected families, the parental CD4/CD8 ratio significantly influenced the ratio in offspring. Complex segregation analysis of the data rejected the non-genetic hypothesis; among the genetic models tested, a major recessive gene with a polygenic component and random environmental effects was the most parsimonious model. These findings indicate that the ratio of CD4+ and CD8+ T cells is genetically controlled in humans.
我们研究了健康供体群体中循环CD4+和CD8+ T淋巴细胞比例的遗传模式。男性和女性的CD4/CD8比例分布存在显著差异，且受年龄显著影响。在46个随机选择的家庭中，父母的CD4/CD8比例对后代的该比例有显著影响。对数据进行的复杂分离分析否定了非遗传假说；在测试的遗传模型中，具有多基因成分和随机环境效应的主要隐性基因是最简约的模型。这些发现表明，人类CD4+和CD8+ T细胞的比例受遗传控制。
