Sun K, Wu Q, Wang J
School of Stomatology, Beijing Medical University.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1995 May;30(3):148-50, 192.
Biopsies from 7 patients with white sponge nevus were examined histologically. Two of them had family history. Light microscopic observation reveals that the epithelium was thickened; the spinous cell layers had enlarged and oedematous cells and ballon-like degeneration; the keratohyalin granules were increased in upper spinous cells; the superficial layers of epithelium exhibited parakeratosis and thickening. 3 specimens were examined by electron microscopy. The basal and parabasal cells were cylindrical. The cytoplasmic tonofilaments were aggregated into boundles. It was characteristics of keratinized epithelium. In middle and superficial stratum spinosum the tonofilaments were homogeneously distributed in the cell plasma and the electron-dense granulars were located near the cell boundary and attached to desmosomes by tonofilaments, unlike normal non-keratinized oral mucosa. Many Odland bodies with a lamellar structure and irregular in both size and shape were seen. It is concluded that this leasion have a dyskeratinized process. The characteristic features of keratinized oral mucosa in non-keratinized mucosa is appeared. The thickening of superficial layer is due to shedding disturbance relating to dysfunction of Odland bodies.
对7例白色海绵状痣患者的活检组织进行了组织学检查。其中2例有家族史。光镜观察显示上皮增厚；棘细胞层细胞增大、水肿，呈气球样变性；棘层上部透明角质颗粒增多；上皮表层出现不全角化和增厚。对3个标本进行了电镜检查。基底细胞和副基底细胞呈柱状。细胞质张力丝聚集成束。这是角化上皮的特征。与正常非角化口腔黏膜不同，在棘层中层和表层，张力丝均匀分布于细胞质中，电子致密颗粒位于细胞边界附近，并通过张力丝附着于桥粒。可见许多具有层状结构、大小和形状不规则的奥尔德小体。结论是该病变存在角化异常过程。非角化黏膜中出现了角化口腔黏膜的特征性表现。表层增厚是由于与奥尔德小体功能障碍相关的脱落紊乱所致。
