Zhang Q, Liao G, Yin H
Department of Pharmaceutics, School of Pharmacy.
Hua Xi Yi Ke Da Xue Xue Bao. 1995 Jun;26(2):172-6.
Several formulations of gentamicin nanoparticle (GM-NP) colloids were prepared by the emulsion polymerization technique using the polybutylcyanoacrylate as the carrier. Various kinds of physicochemical characteristics, such as particle size and size distribution, drug loading and associating ratio, surface zeta potential, surface tension, turbidity, relative density, viscosity, refractive index and acidity were observed, determinated and compared. The results of the experiments have contributed to a full understanding of the physicochemical characteristics of gentamicin nanoparticles and also provided a basis for the establishment of the quality evaluation methods.
采用乳液聚合法，以聚氰基丙烯酸丁酯为载体，制备了几种庆大霉素纳米颗粒（GM-NP）胶体。观察、测定并比较了各种物理化学特性，如粒径和粒径分布、载药量和结合率、表面zeta电位、表面张力、浊度、相对密度、粘度、折射率和酸度。实验结果有助于全面了解庆大霉素纳米颗粒的物理化学特性，也为建立质量评价方法提供了依据。
