Zhang Q, Liao G T
West China University of Medical Sciences, Chengdu.
Yao Xue Xue Bao. 1995;30(6):459-65.
The in vitro release characteristics of gentamicin sulfate polybutylcyanoacrylate nanoparticles were studied using a dialysis system comprising dialysis bag and receptor chamber. The whole apparatus was placed in a water bath shaker thermostated at 37 degrees C, and shaken at 50 cpm. The concentration of gentamicin in the receptor chamber was periodically determined by first derivative spectrometry. The results showed that the in vitro release of gentamicin sulfate from polybutylcyanoacrylate nanoparticles is characteristically biphasic, with an initial fast release (the burst effect), followed by a much slower release. These release profiles can be well modelled using a biexponential function. The related parameters of release kinetics have been calculated according to the biexponential function, and some factors that may affect the release characteristics were studied.
使用由透析袋和接受室组成的透析系统研究了硫酸庆大霉素聚氰基丙烯酸正丁酯纳米粒的体外释放特性。整个装置置于37℃恒温的水浴振荡器中，以50次/分钟的速度振荡。通过一阶导数光谱法定期测定接受室中庆大霉素的浓度。结果表明，硫酸庆大霉素从聚氰基丙烯酸正丁酯纳米粒的体外释放具有典型的双相性，先是快速初始释放（突释效应），随后释放速度慢得多。这些释放曲线可用双指数函数很好地模拟。根据双指数函数计算了释放动力学的相关参数，并研究了一些可能影响释放特性的因素。
