An expectation maximization reconstruction algorithm for emission tomography with non-uniform entropy prior.

A Bayesian image reconstruction algorithm is proposed for emission tomography. It incorporates the Poisson nature of the noise in the projection data and uses a non-uniform entropy as an a priori probability distribution of the image in a maximum a posteriori (MAP) approach. The expectation maximization (EM) method was applied to find the MAP estimator. The Newton-Raphson numerical method whose convergence and positive solutions are proven, was used to solve the EM problem. The prior mean at iteration k was determined by smoothing the image obtained at iteration k-1. Comparisons between the ML and the MAP algorithm were carried out with a numerical phantom that contains a narrow valley region. The ML solution after 50 iterations was chosen as the initial solution for the MAP algorithm, since the global performance of the ML algorithm deteriorates with increasing number of iterations while its local performance in the valley region is always improving. The resulting algorithm is a compromise between ML who has the best local performance in the valley region and the MAP who has the best global performance.